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Mini Dragon Group (ages 6-7)

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Oliver Parker
Oliver Parker

Refocus 6 For Mac Review



Cerebral palsy (CP) is heterogeneous with different clinical types, comorbidities, brain imaging patterns, causes, and now also heterogeneous underlying genetic variants. Few are solely due to severe hypoxia or ischemia at birth. This common myth has held back research in causation. The cost of litigation has devastating effects on maternity services with unnecessarily high cesarean delivery rates and subsequent maternal morbidity and mortality. CP rates have remained the same for 50 years despite a 6-fold increase in cesarean birth. Epidemiological studies have shown that the origins of most CP are prior to labor. Increased risk is associated with preterm delivery, congenital malformations, intrauterine infection, fetal growth restriction, multiple pregnancy, and placental abnormalities. Hypoxia at birth may be primary or secondary to preexisting pathology and international criteria help to separate the few cases of CP due to acute intrapartum hypoxia. Until recently, 1-2% of CP (mostly familial) had been linked to causative mutations. Recent genetic studies of sporadic CP cases using new-generation exome sequencing show that 14% of cases have likely causative single-gene mutations and up to 31% have clinically relevant copy number variations. The genetic variants are heterogeneous and require function investigations to prove causation. Whole genome sequencing, fine scale copy number variant investigations, and gene expression studies may extend the percentage of cases with a genetic pathway. Clinical risk factors could act as triggers for CP where there is genetic susceptibility. These new findings should refocus research about the causes of these complex and varied neurodevelopmental disorders.




Refocus 6 For Mac Review



This program is simple to use and has a no-nonsense approach. The central pane contains previews of the source images, and the final composite when it is finished. The right pane contains details of source images and the controls for the focus stacking process.


Once you have done the above, the program will combine and render the images automatically. Whereas the speed of Photoshop varies, we noticed that process times for Helicon appear consistent. The program renders images quickly and you are presented with a preview of the finished image in a matter of seconds.


As with the other programs, Zerene Stacker is user-friendly and easy to use. The interface looks a little dated, but the menus and controls are logically placed. This main interface is split into three panels. First, the central panel shows previews of the files. Next, the top, left-hand panel shows the source image. Finally, the bottom-left panel displays the final merged image.


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